A nutrigenomic analysis, based on the principles of cancer immunotherapy

You have found the ImmunoDiet™.  Continue to learn about how our nutrigenomics-guided food avoidance is designed to support immune recognition of cancer.

Innovation makes your food choice as personal as the development of a unique cancer vaccine just for you.

Cancer vaccines are a group of therapies with one thing in common, they are designed to help the immune system react against something that is not like you. For example, a mutated protein in a cancer cell.

How is this possible?  The answer to this question begins with a basic understanding of how a cancer vaccine works.

Living organisms, like humans, are composed of many different proteins, and these are the building blocks of “self”. The design of each building block is encoded in the DNA we are born with. The immune system is like an inspector, looking at all the pieces of protein and checking if they are similar to the parts that are described in our DNA. When a part passes inspection, the immune system moves on to the next part, but if the part fails inspection then the immune system will try to remove the “non-self” parts in our body.

The main inspectors who work for us in the immune system to recognize “self” from “non-self” are T cells. Each T cells is trained to inspect only a limited number of parts, so millions of T cells work together to inspect all the parts of our proteins in the body and recognize and react to mutated cancer proteins. Since humans have over 25,000 proteins and each T cell can only inspect a small part of each protein at a time, this is a large and diverse workforce.

Cancer vaccines are designed to work like a recall notice that goes out to all the inspectors to increase the effort to look for specific broken parts.

This is like when a car company sends out a recall notice. The car dealers have been notified of what to look for and are ready to remove the defective parts from all the cars out on the road that might be affected. The ingredients in the vaccine tell the T cells what parts of which protein to look for and increase the ability of the immune system to remove the mutated cancer cells from the body.

This food avoidance diet is made possible with deep genomic computation

Pioneering a new application of immunotherapy concepts that uses the DNA sequence of food sources as a way to establish a behavior intervention at the level of food avoidance.  This behavior, avoiding foods identified in one’s ImmunoDiet™ Report, will alter the presence of peptides believed to weaken the immune response to cancer.

By using your tumor exome or whole genome sequencing data, and normal genome data, you are eligible to purchase the ImmunoDiet™ analysis.  If you do not yet have the required DNA sequencing files, you may still be eligible for the ImmunoDiet™+SEQ service.  Experience the comfort of having performed a thorough search of food for peptides that may interfere with the recognition of cancer cells by your immune system.

“…advances in next-generation sequencing and epitope prediction now permit the rapid identification of mutant tumor neoantigens.”

– Gubin, et.al. Journal of Clinical Oncology 2015

Oral tolerance can be reversed. Alleviating oral tolerance to cancer is the goal of each ImmunoDiet™ analysis.

“Oral tolerance is the state of local and systemic immune unresponsiveness that is induced by oral administration of innocuous antigen such as food proteins.” 

– Pabst et.al 2012 Mucosal Immunology

“Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active suppression, whereas higher doses favor clonal anergy/deletion.” – A.M. Faria, Ph.D. – Immunological Reviews

Want to know what the ImmunoDiet™ is testing? 

Answer: Mutated Molecular Mimics

1.   T cells recognize tumor specific proteins, many of these targets are formed by mutations in cancer cells that result in 100% mimicry of peptides in other species. 

2.   Tumor specific proteins in the digestive tracts suppress T cells through the multiple mechanism of oral tolerance.

3.    ImmunoDiet™ Report contains the number of Mutated Molecular Mimics  found in each edible species. (M3 Peptides)  The more M3 Peptides the more likely that food will suppress the cancer specific immune response.

What you can expect as an ImmunoDiet™ user?

The detection of M3 peptides in foods is supported by plant, animal and microorganism genome sequencing efforts.  Our ability to expand beyond the 8000+ species of edible organisms is growing, and so will your ImmunoDiet™ Report.  As more genes are sequences, you can expect your report to grow at the rate of this scientific progress; linking your dietary management plan to the front edge of science.

Consistent

If the immune system is tolerant to cancer’s presence, the tolerance becomes a therapeutic target.  The association of Red Meat with Cancer is consistent with ImmunoDiet™ science.               

Accurate

If a specific target on the cancer cell is 100% identical to a peptide in food, that food can be avoided.  ImmunoDiet™ results are provided at the species level and your dietary professional will help.

Updates

As we sequence more foods, more sources of your personal M3 peptides will be found.  Keep your ImmunoDiet™ report current, register for notifications of updates in your online account.